Metabolism of postsynaptic recombination intermediates
نویسندگان
چکیده
منابع مشابه
Resolution of Recombination Intermediates: Mechanisms and Regulation.
DNA strand break repair by homologous recombination leads to the formation of intermediates in which sister chromatids are covalently linked. The efficient processing of these joint molecules, which often contain four-way structures known as Holliday junctions, is necessary for efficient chromosome segregation during mitotic division. Because persistent chromosome bridges pose a threat to genom...
متن کاملAlkylating intermediates in nitrosamine metabolism.
Baird, W. M.,Dipple, A.,Grover,P. L.,Sims,P. &Brookes,P. (1973) Cancer Res. 33,2386-2392 Booth, J. & Sims, P. (1974~) Biochem. Pharmacol. 23,2547-2555 Booth, J. & Sims, P. (1974b) FEBS Lett. 47,30-33 Booth, J., Keysell, G. R. & Sims, P. (1973) Biochem. Pharmacol. 22,1781-1791 Booth, J., Keysell, G. R., Pal, K. & Sims, P. (1974) FEBS Lett. 43,341-344 Boyland, E. (1950) Biochem. SOC. Symp. 5,4044...
متن کاملIdentification of double holliday junctions as intermediates in meiotic recombination
During meiosis, branched DNA molecules containing information from both parental chromosomes occur in vivo at loci where meiosis-specific double-stranded breaks occur. We demonstrate here that these joint molecules are recombination intermediates: they contain single strands that have undergone exchange of information. Moreover, these joint molecules are resolved into both parental and recombin...
متن کاملSingle Holliday Junctions Are Intermediates of Meiotic Recombination
Crossing-over between homologous chromosomes facilitates their accurate segregation at the first division of meiosis. Current models for crossing-over invoke an intermediate in which homologs are connected by two crossed-strand structures called Holliday junctions. Such double Holliday junctions are a prominent intermediate in Saccharomyces cerevisiae meiosis, where they form preferentially bet...
متن کاملSrs2 promotes Mus81–Mms4-mediated resolution of recombination intermediates
A variety of DNA lesions, secondary DNA structures or topological stress within the DNA template may lead to stalling of the replication fork. Recovery of such forks is essential for the maintenance of genomic stability. The structure-specific endonuclease Mus81-Mms4 has been implicated in processing DNA intermediates that arise from collapsed forks and homologous recombination. According to pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 2010
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2010.05.023